2n7e

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'''Unreleased structure'''
 
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The entry 2n7e is ON HOLD until Paper Publication
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==UBL domain of the yeast DNA damage-inducible protein homolog 1==
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<StructureSection load='2n7e' size='340' side='right' caption='[[2n7e]], [[NMR_Ensembles_of_Models | 43 NMR models]]' scene=''>
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Authors: Siva, M., Grantz Saskova, K., Veverka, V.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n7e]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7E FirstGlance]. <br>
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Description: UBL domain of the yeast DNA damage-inducible protein homolog 1
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n7d|2n7d]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7e OCA], [http://pdbe.org/2n7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7e RCSB], [http://www.ebi.ac.uk/pdbsum/2n7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Saskova, K Grantz]]
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[[Category: Siva, M]]
[[Category: Veverka, V]]
[[Category: Veverka, V]]
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[[Category: Grantz Saskova, K]]
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[[Category: Ddi1]]
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[[Category: Siva, M]]
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[[Category: Unknown function]]

Revision as of 15:23, 26 July 2016

UBL domain of the yeast DNA damage-inducible protein homolog 1

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