4z9k
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Ricin A chain bound to camelid nanobody (VHH2)(F5)== | |
| - | + | <StructureSection load='4z9k' size='340' side='right' caption='[[4z9k]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z9k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z9K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lgp|4lgp]], [[4lgr|4lgr]], [[4lhj|4lhj]], [[4lhq|4lhq]], [[4lgs|4lgs]], [[5boz|5boz]]</td></tr> |
| - | [[Category: Rudolph, M | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9k OCA], [http://pdbe.org/4z9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z9k RCSB], [http://www.ebi.ac.uk/pdbsum/4z9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z9k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: RRNA N-glycosylase]] | ||
| + | [[Category: Rudolph, M J]] | ||
| + | [[Category: Hydrolase-immune system complex]] | ||
| + | [[Category: Nanobody]] | ||
| + | [[Category: Ricin toxin]] | ||
Revision as of 15:24, 26 July 2016
Ricin A chain bound to camelid nanobody (VHH2)(F5)
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