5awa
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human TLR8 in complex with MB-568== | |
| - | + | <StructureSection load='5awa' size='340' side='right' caption='[[5awa]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5awa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AWA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=M8D:5-[[3-(AMINOMETHYL)PHENYL]METHYL]-3-PENTYL-QUINOLIN-2-AMINE'>M8D</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5awb|5awb]], [[5awc|5awc]], [[5awd|5awd]]</td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5awa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5awa OCA], [http://pdbe.org/5awa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5awa RCSB], [http://www.ebi.ac.uk/pdbsum/5awa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5awa ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ohto, U]] | [[Category: Ohto, U]] | ||
[[Category: Shimizu, T]] | [[Category: Shimizu, T]] | ||
| + | [[Category: Tanji, H]] | ||
| + | [[Category: Adjuvant]] | ||
| + | [[Category: Glycosylation]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Linnate immunity]] | ||
| + | [[Category: Tlr8]] | ||
| + | [[Category: Vaccine adjuvant]] | ||
Revision as of 15:25, 26 July 2016
Crystal structure of human TLR8 in complex with MB-568
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