5chz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of wild-type human MBD4 bound to a G:T mismatch== | |
| - | + | <StructureSection load='5chz' size='340' side='right' caption='[[5chz]], [[Resolution|resolution]] 1.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5chz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CHZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ofa|4ofa]], [[4ofe|4ofe]], [[4ofh|4ofh]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5chz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5chz OCA], [http://pdbe.org/5chz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5chz RCSB], [http://www.ebi.ac.uk/pdbsum/5chz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5chz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lee, S]] | ||
| + | [[Category: Lin, Y L]] | ||
| + | [[Category: Ouzon-Shubeita, H]] | ||
| + | [[Category: Dna glycosylase]] | ||
| + | [[Category: G:t mismatch]] | ||
| + | [[Category: Hmbd4]] | ||
| + | [[Category: Hydrolase-dna complex]] | ||
Revision as of 15:27, 26 July 2016
Structure of wild-type human MBD4 bound to a G:T mismatch
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