1k5m
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[4rhv|4rhv]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5m OCA], [http://www.ebi.ac.uk/pdbsum/1k5m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k5m RCSB]</span> | ||
}} | }} | ||
| Line 16: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1K5M is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1K5M is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K5M OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1., Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E, Structure. 2002 Jul;10(7):999-1011. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12121655 12121655] | Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1., Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E, Structure. 2002 Jul;10(7):999-1011. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12121655 12121655] | ||
| - | [[Category: Human rhinovirus | + | [[Category: Human rhinovirus 14]] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Arnold, E.]] | [[Category: Arnold, E.]] | ||
| Line 28: | Line 31: | ||
[[Category: Ma, X.]] | [[Category: Ma, X.]] | ||
[[Category: Smith, A D.]] | [[Category: Smith, A D.]] | ||
| - | [[Category: SPH]] | ||
[[Category: beta turn]] | [[Category: beta turn]] | ||
[[Category: engineered rhinovirus]] | [[Category: engineered rhinovirus]] | ||
| Line 34: | Line 36: | ||
[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:46 2008'' |
Revision as of 18:43, 30 March 2008
| |||||||
| , resolution 2.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Related: | 4rhv
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 V3 Loop Chimeric Virus MN-III-2
Overview
We report the 2.7 A resolution structure of a chimeric rhinovirus, MN-III-2, that displays part of the HIV-1 gp120 V3 loop and elicits HIV-neutralizing antibodies. The V3 loop insert is dominated by two type I beta turns. The structures of two adjacent tripeptides resemble those of analogous segments in three Fab/V3 loop peptide complexes. Although two of the three corresponding antibodies bind and neutralize MN-III-2 well, only one of the three can bind without significant rearrangement. These results suggest that the V3 loop insert: (1) can share some local conformational similarity to V3 loop sequences presented on different structural frameworks; (2) must be able to adopt multiple conformations, even in a relatively constrained environment; and (3) may mimic the conformational variability of the epitope on HIV-1, increasing the likelihood of eliciting appropriate neutralizing immune responses.
About this Structure
1K5M is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.
Reference
Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1., Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E, Structure. 2002 Jul;10(7):999-1011. PMID:12121655
Page seeded by OCA on Sun Mar 30 21:43:46 2008
