5fcn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==microtubule binding domain of human CEP135== | |
| - | + | <StructureSection load='5fcn' size='340' side='right' caption='[[5fcn]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fcn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FCN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fcn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcn OCA], [http://pdbe.org/5fcn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcn RCSB], [http://www.ebi.ac.uk/pdbsum/5fcn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcn ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CP135_HUMAN CP135_HUMAN]] Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP135_HUMAN CP135_HUMAN]] Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole.<ref>PMID:17681131</ref> <ref>PMID:18851962</ref> <ref>PMID:26675238</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kraatz, S H.W]] | ||
| + | [[Category: Centriole]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Microtubule-binding protein]] | ||
Revision as of 15:32, 26 July 2016
microtubule binding domain of human CEP135
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