1k64
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1k64 |SIZE=350|CAPTION= <scene name='initialview01'>1k64</scene> | |PDB= 1k64 |SIZE=350|CAPTION= <scene name='initialview01'>1k64</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1plp|1PLP]], [[1qs3|1QS3]], [[1dg2|1DG2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k64 OCA], [http://www.ebi.ac.uk/pdbsum/1k64 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k64 RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Park, K H.]] | [[Category: Park, K H.]] | ||
[[Category: Suk, J E.]] | [[Category: Suk, J E.]] | ||
| - | [[Category: NH2]] | ||
[[Category: omega-shaped containing a-helix]] | [[Category: omega-shaped containing a-helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:57 2008'' |
Revision as of 18:44, 30 March 2008
| |||||||
| Ligands: | , | ||||||
| Related: | 1PLP, 1QS3, 1DG2
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Structue of alpha-conotoxin EI
Overview
A high resolution structure of alpha-conotoxin EI has been determined by (1)H NMR spectroscopy and molecular modeling. alpha-Conotoxin EI has the same disulfide framework as alpha 4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the neuromuscular receptor as do the alpha 3/5 and alpha A conotoxins. The unique binding preference of alpha-conotoxin EI to the alpha(1)/delta subunit interface of Torpedo neuromuscular receptor makes it a valuable structural template for superposition of various alpha-conotoxins possessing distinct receptor subtype specificities. Structural comparison of alpha-conotoxin EI with the gamma-subunit favoring alpha-conotoxin GI suggests that the Torpedo delta-subunit preference of the former originates from its second loop. Superposition of three-dimensional structures of seven alpha-conotoxins reveals that the estimated size of the toxin-binding pocket in nicotinic acetylcholine receptor is approximately 20 A (height) x 20 A (width) x 15 A (thickness).
About this Structure
1K64 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor., Park KH, Suk JE, Jacobsen R, Gray WR, McIntosh JM, Han KH, J Biol Chem. 2001 Dec 28;276(52):49028-33. Epub 2001 Oct 18. PMID:11641403
Page seeded by OCA on Sun Mar 30 21:43:57 2008
