5hyp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein== | |
| - | + | <StructureSection load='5hyp' size='340' side='right' caption='[[5hyp]], [[Resolution|resolution]] 3.02Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyt|5hyt]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [http://pdbe.org/5hyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [http://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr> |
| - | [[Category: Bahn-Suh, A | + | </table> |
| - | [[Category: Buffalo, C | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bahn-Suh, A J]] | ||
| + | [[Category: Buffalo, C Z]] | ||
[[Category: Ghosh, P]] | [[Category: Ghosh, P]] | ||
| + | [[Category: Complement]] | ||
| + | [[Category: Hypervariable antigen]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: M protein]] | ||
| + | [[Category: Streptococcus pyogene]] | ||
Revision as of 15:34, 26 July 2016
Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein
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