5hyt
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M22 protein== | |
| - | + | <StructureSection load='5hyt' size='340' side='right' caption='[[5hyt]], [[Resolution|resolution]] 2.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hyt]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyp|5hyp]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyt OCA], [http://pdbe.org/5hyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyt RCSB], [http://www.ebi.ac.uk/pdbsum/5hyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyt ProSAT]</span></td></tr> |
| - | [[Category: Bahn-Suh, A | + | </table> |
| - | [[Category: Buffalo, C | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bahn-Suh, A J]] | ||
| + | [[Category: Buffalo, C Z]] | ||
[[Category: Ghosh, P]] | [[Category: Ghosh, P]] | ||
| + | [[Category: Complement]] | ||
| + | [[Category: Hypervariable antigen]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: M protein]] | ||
| + | [[Category: Streptococcus pyogene]] | ||
Revision as of 15:34, 26 July 2016
Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M22 protein
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