1k68
From Proteopedia
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|PDB= 1k68 |SIZE=350|CAPTION= <scene name='initialview01'>1k68</scene>, resolution 1.90Å | |PDB= 1k68 |SIZE=350|CAPTION= <scene name='initialview01'>1k68</scene>, resolution 1.90Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= AF309559 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1188 Tolypothrix sp. PCC 7601]) | |GENE= AF309559 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1188 Tolypothrix sp. PCC 7601]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1k66|1K66]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k68 OCA], [http://www.ebi.ac.uk/pdbsum/1k68 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k68 RCSB]</span> | ||
}} | }} | ||
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[[Category: Marsac, N Tandeau de.]] | [[Category: Marsac, N Tandeau de.]] | ||
[[Category: Scheufler, C.]] | [[Category: Scheufler, C.]] | ||
| - | [[Category: MG]] | ||
[[Category: (beta/alpha)5]] | [[Category: (beta/alpha)5]] | ||
[[Category: chey homologue]] | [[Category: chey homologue]] | ||
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[[Category: response regulator]] | [[Category: response regulator]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:01 2008'' |
Revision as of 18:44, 30 March 2008
| |||||||
| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | AF309559 (Tolypothrix sp. PCC 7601) | ||||||
| Related: | 1K66
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the Phosphorylated Cyanobacterial Phytochrome Response Regulator RcpA
Overview
The structures of two response regulators (RRs) from the cyanobacterium Calothrix PCC7601, RcpA and RcpB, were solved to 1.9- and 1.75-A resolution, respectively. RcpA was found in phosphorylated and RcpB in nonphosphorylated form. Both RRs are members of phytochrome-associated, light-sensing two-component signal transduction pathways, based on histidine kinase-mediated receptor autophosphorylation and phosphorelay to a RR. Despite the overall folding similarity to CheY-type RRs ((beta/alpha)(5)-motif), RcpA and RcpB form homodimers, irrespective of their phosphorylation state, giving insight into a signal transduction putatively different from that of other known RRs. Dimerization is accomplished by a C-terminal extension of the RR polypeptide chain, and the surface formed by H4, beta 5, and H5, which constitute a hydrophobic contact area with distinct interactions between residues of either subunit. Sequence alignments reveal that the identified dimerization motif is archetypal for phytochrome-associated RRs, making them a novel subgroup of CheY-type RRs. The protein structures of RcpA and RcpB are compared to the recently presented protein structure of Rcp1 from Synechocystis.
About this Structure
1K68 is a Single protein structure of sequence from Tolypothrix sp. pcc 7601. Full crystallographic information is available from OCA.
Reference
Crystal structures of two cyanobacterial response regulators in apo- and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators., Benda C, Scheufler C, Tandeau de Marsac N, Gartner W, Biophys J. 2004 Jul;87(1):476-87. PMID:15240481
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