5i0q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein== | |
| - | + | <StructureSection load='5i0q' size='340' side='right' caption='[[5i0q]], [[Resolution|resolution]] 2.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyp|5hyp]], [[5hyt|5hyt]], [[5hzp|5hzp]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0q OCA], [http://pdbe.org/5i0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0q RCSB], [http://www.ebi.ac.uk/pdbsum/5i0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0q ProSAT]</span></td></tr> |
| - | [[Category: Bahn-Suh, A | + | </table> |
| - | [[Category: Buffalo, C | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bahn-Suh, A J]] | ||
| + | [[Category: Buffalo, C Z]] | ||
[[Category: Ghosh, P]] | [[Category: Ghosh, P]] | ||
| + | [[Category: Complement]] | ||
| + | [[Category: Hypervariable antigen]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: M protein]] | ||
| + | [[Category: Streptococcus pyogene]] | ||
Revision as of 15:35, 26 July 2016
Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein
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