4wwv
From Proteopedia
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==Aminopeptidase APDkam598 from the archaeon Desulfurococcus kamchatkensis== | ==Aminopeptidase APDkam598 from the archaeon Desulfurococcus kamchatkensis== | ||
<StructureSection load='4wwv' size='340' side='right' caption='[[4wwv]], [[Resolution|resolution]] 3.01Å' scene=''> | <StructureSection load='4wwv' size='340' side='right' caption='[[4wwv]], [[Resolution|resolution]] 3.01Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4wwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WWV FirstGlance]. <br> | <table><tr><td colspan='2'>[[4wwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WWV FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xfo|1xfo]], [[1y0f|1y0f]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xfo|1xfo]], [[1y0f|1y0f]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wwv RCSB], [http://www.ebi.ac.uk/pdbsum/4wwv PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wwv OCA], [http://pdbe.org/4wwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wwv RCSB], [http://www.ebi.ac.uk/pdbsum/4wwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wwv ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the aminopeptidase APDkam589 from the thermophilic crenarchaeon Desulfurococcus kamchatkensis was determined at a resolution of 3.0 A. In the crystal, the monomer of APDkam589 and its symmetry-related monomers are densely packed to form a 12-subunit complex. Single-particle electron-microscopy analysis confirms that APDkam589 is present as a compact dodecamer in solution. The APDkam589 molecule is built similarly to the molecules of the PhTET peptidases, which have the highest sequence identity to APDkam589 among known structures and were isolated from the more thermostable archaeon Pyrococcus horikoshii. A comparison of the interactions of the subunits in APDkam589 with those in PhTET1, PhTET2 and PhTET3 reveals that APDkam589 has a much lower total number of salt bridges, which correlates with the lower thermostability of APDkam589. The monomer of APDkam589 has six Trp residues, five of which are on the external surface of the dodecamer. A superposition of the structure of APDkam589 with those having a high sequence similarity to APDkam589 reveals that, although the positions of Trp45, Trp252 and Trp358 are not conserved in the sequences, the spatial locations of the Trp residues in these models are similar. | ||
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| + | Structure of the dodecamer of the aminopeptidase APDkam598 from the archaeon Desulfurococcus kamchatkensis.,Petrova TE, Slutskaya ES, Boyko KM, Sokolova OS, Rakitina TV, Korzhenevskiy DA, Gorbacheva MA, Bezsudnova EY, Popov VO Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):277-85. doi:, 10.1107/S2053230X15000783. Epub 2015 Feb 19. PMID:25760701<ref>PMID:25760701</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4wwv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:55, 27 July 2016
Aminopeptidase APDkam598 from the archaeon Desulfurococcus kamchatkensis
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