1k83
From Proteopedia
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|PDB= 1k83 |SIZE=350|CAPTION= <scene name='initialview01'>1k83</scene>, resolution 2.80Å | |PDB= 1k83 |SIZE=350|CAPTION= <scene name='initialview01'>1k83</scene>, resolution 2.80Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=ILX:4,5-DIHYDROXYISOLEUCINE'>ILX</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRX:6-HYDROXYTRYPTOPHAN'>TRX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1i50|1I50]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k83 OCA], [http://www.ebi.ac.uk/pdbsum/1k83 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k83 RCSB]</span> | ||
}} | }} | ||
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[[Category: Cramer, P.]] | [[Category: Cramer, P.]] | ||
[[Category: Kornberg, R D.]] | [[Category: Kornberg, R D.]] | ||
| - | [[Category: MN]] | ||
| - | [[Category: ZN]] | ||
[[Category: alpha amanitin]] | [[Category: alpha amanitin]] | ||
[[Category: molecular machine]] | [[Category: molecular machine]] | ||
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[[Category: zinc motif]] | [[Category: zinc motif]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:41 2008'' |
Revision as of 18:44, 30 March 2008
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , | ||||||
| Activity: | DNA-directed RNA polymerase, with EC number 2.7.7.6 | ||||||
| Related: | 1I50
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin
Overview
The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
About this Structure
1K83 is a Protein complex structure of sequences from Amanita phalloides and Saccharomyces cerevisiae. The following page contains interesting information on the relation of 1K83 with [RNA Polymerase]. Full crystallographic information is available from OCA.
Reference
Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution., Bushnell DA, Cramer P, Kornberg RD, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1218-22. Epub 2002 Jan 22. PMID:11805306
Page seeded by OCA on Sun Mar 30 21:44:41 2008
