1k8i
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= H2-DM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= H2-DM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8i OCA], [http://www.ebi.ac.uk/pdbsum/1k8i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k8i RCSB]</span> | ||
}} | }} | ||
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[[Category: Kappler, J.]] | [[Category: Kappler, J.]] | ||
[[Category: Marrack, P.]] | [[Category: Marrack, P.]] | ||
| - | [[Category: NAG]] | ||
[[Category: mhc]] | [[Category: mhc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:54 2008'' |
Revision as of 18:44, 30 March 2008
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| , resolution 3.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | H2-DM (Mus musculus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MOUSE H2-DM
Overview
H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where it facilitates the loading of antigenic peptides into the peptide-binding groove of class II MHC. The crystal structure of a soluble form of H2-M has been solved to 3.1 A resolution, revealing a heterodimer with structural similarities to the MHC family of proteins. In contrast to its antigen-presenting cousins, the membrane distal alpha helices of H2-M pack closely together, occluding most of the binding groove except for a single large pocket near the center. The structure of H2-M has several unique features that may play a role in its function as a molecular chaperone and peptide exchange factor.
About this Structure
1K8I is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:9768758
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