5ax9

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'''Unreleased structure'''
 
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The entry 5ax9 is ON HOLD until Paper Publication
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==Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase in complex with compund 9==
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<StructureSection load='5ax9' size='340' side='right' caption='[[5ax9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ax9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AX9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4KT:4-METHOXY-3-[2-[(3-METHOXY-4-MORPHOLIN-4-YL-PHENYL)AMINO]PYRIDIN-4-YL]BENZENECARBONITRILE'>4KT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ax9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ax9 OCA], [http://pdbe.org/5ax9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ax9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ax9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ax9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNIK_HUMAN TNIK_HUMAN]] Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.<ref>PMID:10521462</ref> <ref>PMID:15342639</ref> <ref>PMID:19061864</ref> <ref>PMID:19816403</ref> <ref>PMID:20159449</ref> <ref>PMID:21690388</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Kukimoto-Niino, M]]
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[[Category: Ohbayashi, N]]
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[[Category: Shirouzu, M]]
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[[Category: Yamada, T]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 15:33, 27 July 2016

Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase in complex with compund 9

5ax9, resolution 2.40Å

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