5cwz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase== | |
| - | + | <StructureSection load='5cwz' size='340' side='right' caption='[[5cwz]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cwz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CWZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cwz OCA], [http://pdbe.org/5cwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cwz RCSB], [http://www.ebi.ac.uk/pdbsum/5cwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cwz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TNIK_HUMAN TNIK_HUMAN]] Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.<ref>PMID:10521462</ref> <ref>PMID:15342639</ref> <ref>PMID:19061864</ref> <ref>PMID:19816403</ref> <ref>PMID:20159449</ref> <ref>PMID:21690388</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Kukimoto-Niino, M]] | ||
[[Category: Ohbayashi, N]] | [[Category: Ohbayashi, N]] | ||
| - | [[Category: | + | [[Category: Shirouzu, M]] |
[[Category: Yamada, T]] | [[Category: Yamada, T]] | ||
| - | [[Category: | + | [[Category: Kinase]] |
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 15:36, 27 July 2016
Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase
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