5j4a
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein== | |
| - | + | <StructureSection load='5j4a' size='340' side='right' caption='[[5j4a]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j4a]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J4A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5j5v|5j5v]], [[5j43|5j43]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j4a OCA], [http://pdbe.org/5j4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j4a RCSB], [http://www.ebi.ac.uk/pdbsum/5j4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j4a ProSAT]</span></td></tr> |
| - | [[Category: Johnson, P | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/CDIA9_BURPE CDIA9_BURPE]] Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. The C-terminal 160 residues (CT domain) acts as a general tRNA nuclease, and inhibits growth in E.coli. Cleaves specifically within the T-loop of E.coli tRNA2(Arg). Toxic activity is neutralized by coexpression of the cognate immunity protein CdiI in E.coli, but not by non-cognate immunity proteins from other strains of B.pseudomallei.<ref>PMID:22435733</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Goulding, C W]] | ||
| + | [[Category: Johnson, P M]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Endonuclease]] | ||
| + | [[Category: Immunity protein]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 15:45, 27 July 2016
CdiA-CT toxin from Burkholderia pseudomallei E479 in complex with cognate CdiI immunity protein
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