5jyg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the MamK filament at 6.5 A== | |
| + | <StructureSection load='5jyg' size='340' side='right' caption='[[5jyg]], [[Resolution|resolution]] 6.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5jyg]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYG FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyg OCA], [http://pdbe.org/5jyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyg RCSB], [http://www.ebi.ac.uk/pdbsum/5jyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Magnetotactic bacteria possess cellular compartments called magnetosomes that sense magnetic fields. Alignment of magnetosomes in the bacterial cell is necessary for their function, and this is achieved through anchoring of magnetosomes to filaments composed of the protein MamK. MamK is an actin homologue that polymerizes upon ATP binding. Here, we report the structure of the MamK filament at approximately 6.5 A, obtained by cryo-Electron Microscopy. This structure confirms our previously reported double-stranded, non-staggered architecture, and reveals the molecular basis for filament formation. While MamK is closest in sequence to the bacterial actin MreB, the longitudinal contacts along each MamK strand most closely resemble those of eukaryotic actin. In contrast, the cross-strand interface, with a surprisingly limited set of contacts, is novel among actin homologues and gives rise to the non-staggered architecture. This article is protected by copyright. All rights reserved. | ||
| - | + | Structure of the Magnetosome-associated actin-like MamK filament at sub-nanometer resolution.,Bergeron JR, Hutto R, Ozyamak E, Hom N, Hansen J, Draper O, Byrne ME, Keyhani S, Komeili A, Kollman JM Protein Sci. 2016 Jul 8. doi: 10.1002/pro.2979. PMID:27391173<ref>PMID:27391173</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5jyg" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bergeron, J R.C]] | ||
| + | [[Category: Hutto, R]] | ||
| + | [[Category: Kollman, J M]] | ||
| + | [[Category: Actin-like]] | ||
| + | [[Category: Bacteria]] | ||
| + | [[Category: Magnetosome]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 15:46, 27 July 2016
Cryo-EM structure of the MamK filament at 6.5 A
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