Pteridine reductase
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load=' | + | <StructureSection load='2bfp' size='350' side='right' caption='Structure of pteridine reductase complex with NADPH and folate (PDB entry [[2bfp]])' scene=''> |
| + | == Function == | ||
| + | '''Pteridine reductase''' (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism<ref>PMID:12651944</ref>. NADP is the hydrogen acceptor in this reduction. | ||
| - | + | == Relevance == | |
| + | PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. | ||
</StructureSection> | </StructureSection> | ||
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**[[3bmc]] – TbPTR1 + NADPH + folate <BR /> | **[[3bmc]] – TbPTR1 + NADPH + folate <BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:25, 31 July 2016
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3D structures of pteridine reductase
Updated on 31-July-2016
References
- ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
