Pyrin domain

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{{STRUCTURE_2km6| PDB=2km6 | SIZE=300| SCENE=Pyrin_domain/Pyrin_domain/1 |right|CAPTION=NMR structure of pyrin domain in human NLRP7, [[2km6]] }}
{{STRUCTURE_2km6| PDB=2km6 | SIZE=300| SCENE=Pyrin_domain/Pyrin_domain/1 |right|CAPTION=NMR structure of pyrin domain in human NLRP7, [[2km6]] }}
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== Function ==
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'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal<ref>PMID:11514682</ref>.
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'''Pyrin domain''' (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal. Mutations in the protein are the cause of Familial Mediterranean fever.
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== Disease ==
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Mutations in the protein are the cause of Familial Mediterranean fever<ref>PMID:17431422</ref>.
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== 3D Structures of Pyrin domain ==
== 3D Structures of Pyrin domain ==
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[[2dbg]] – hPYD in myeloid cell nuclear differentiation antigen - NMR<BR />
[[2dbg]] – hPYD in myeloid cell nuclear differentiation antigen - NMR<BR />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 06:35, 2 August 2016

Template:STRUCTURE 2km6

Contents

Function

Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal[1].

Disease

Mutations in the protein are the cause of Familial Mediterranean fever[2].

3D Structures of Pyrin domain

2km6 – hPYD in NLRP7 – human – NMR
2wl1 – hPYD PRYSPRY residues 586-776
2do9 – mPYD in NALP10 – mouse – NMR
2yu0 – mPYD in interferon-activable protein 205 - NMR
1pn5 – hPYD in NALP1 - NMR
1ucp - hPYD in apoptosis-associated speck-like protein – NMR
2hm2 – hPYD in apoptosis-associated speck-like protein2 – NMR
2dbg – hPYD in myeloid cell nuclear differentiation antigen - NMR

References

  1. ↑ Fairbrother WJ, Gordon NC, Humke EW, O'Rourke KM, Starovasnik MA, Yin JP, Dixit VM. The PYRIN domain: a member of the death domain-fold superfamily. Protein Sci. 2001 Sep;10(9):1911-8. PMID:11514682 doi:http://dx.doi.org/10.1110/ps.13801
  2. ↑ Papin S, Cuenin S, Agostini L, Martinon F, Werner S, Beer HD, Grutter C, Grutter M, Tschopp J. The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 2007 Aug;14(8):1457-66. Epub 2007 Apr 13. PMID:17431422 doi:http://dx.doi.org/10.1038/sj.cdd.4402142

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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