5jj2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the central domain of human AKAP18 gamma/delta in complex with malonate== | |
| - | + | <StructureSection load='5jj2' size='340' side='right' caption='[[5jj2]], [[Resolution|resolution]] 1.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5jj2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JJ2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jj2 OCA], [http://pdbe.org/5jj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jj2 RCSB], [http://www.ebi.ac.uk/pdbsum/5jj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jj2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AKA7G_HUMAN AKA7G_HUMAN]] Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bjerregaard-Andersen, K]] | ||
| + | [[Category: Morth, J P]] | ||
| + | [[Category: Ostensen, E]] | ||
| + | [[Category: Scott, J D]] | ||
[[Category: Tasken, K]] | [[Category: Tasken, K]] | ||
| - | [[Category: | + | [[Category: A-kinase anchoring]] |
| - | [[Category: | + | [[Category: Akap]] |
| - | [[Category: | + | [[Category: Central domain]] |
| - | [[Category: | + | [[Category: Complex]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Malonate]] | ||
| + | [[Category: Phospoesterase]] | ||
Revision as of 04:17, 4 August 2016
Crystal structure of the central domain of human AKAP18 gamma/delta in complex with malonate
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