5jti

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'''Unreleased structure'''
 
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The entry 5jti is ON HOLD until Paper Publication
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==Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 2==
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<StructureSection load='5jti' size='340' side='right' caption='[[5jti]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5jti]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JTI FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jti OCA], [http://pdbe.org/5jti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jti RCSB], [http://www.ebi.ac.uk/pdbsum/5jti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jti ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cronin, N]]
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[[Category: Guetter, S]]
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[[Category: Mariotti, L]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]

Revision as of 04:18, 4 August 2016

Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 2

5jti, resolution 2.90Å

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