5kdl
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS== | |
| - | + | <StructureSection load='5kdl' size='340' side='right' caption='[[5kdl]], [[Resolution|resolution]] 2.67Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kdl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KDL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kdo|5kdo]]</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdl OCA], [http://pdbe.org/5kdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdl RCSB], [http://www.ebi.ac.uk/pdbsum/5kdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Gilbert, J]] | [[Category: Gilbert, J]] | ||
| - | [[Category: Lokits, A | + | [[Category: Hamm, H E]] |
| + | [[Category: Iverson, T M]] | ||
| + | [[Category: Kaya, A I]] | ||
| + | [[Category: Lokits, A D]] | ||
[[Category: Meiler, J]] | [[Category: Meiler, J]] | ||
| - | [[Category: | + | [[Category: Heterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release]] |
| - | [[Category: | + | [[Category: Signaling protein]] |
| - | + | ||
Revision as of 04:19, 4 August 2016
Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS
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