5kmg
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Near-atomic cryo-EM structure of PRC1 bound to the microtubule== | |
| - | + | <StructureSection load='5kmg' size='340' side='right' caption='[[5kmg]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kmg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KMG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POU:PELORUSIDE+A'>POU</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nrx|3nrx]], [[2nry|2nry]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmg OCA], [http://pdbe.org/5kmg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kmg RCSB], [http://www.ebi.ac.uk/pdbsum/5kmg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/PRC1_HUMAN PRC1_HUMAN]] Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle.<ref>PMID:9885575</ref> <ref>PMID:12082078</ref> <ref>PMID:15297875</ref> <ref>PMID:15625105</ref> <ref>PMID:16431929</ref> <ref>PMID:19468300</ref> <ref>PMID:20691902</ref> [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Chacon, P]] | ||
| + | [[Category: Howes, S]] | ||
| + | [[Category: Kapoor, T M]] | ||
| + | [[Category: Kellogg, E H]] | ||
[[Category: Nogales, E]] | [[Category: Nogales, E]] | ||
| - | [[Category: Howes, S]] | ||
| - | [[Category: Kellogg, E.H]] | ||
[[Category: Ramirez-Aportela, E]] | [[Category: Ramirez-Aportela, E]] | ||
| - | [[Category: Ti, S | + | [[Category: Ti, S C]] |
| - | [[Category: | + | [[Category: Cytoskeleton]] |
| - | [[Category: | + | [[Category: Microtubule]] |
| + | [[Category: Microtubule-associated protein]] | ||
| + | [[Category: Mitosis]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 04:20, 4 August 2016
Near-atomic cryo-EM structure of PRC1 bound to the microtubule
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