1kh6

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|PDB= 1kh6 |SIZE=350|CAPTION= <scene name='initialview01'>1kh6</scene>, resolution 2.9&Aring;
|PDB= 1kh6 |SIZE=350|CAPTION= <scene name='initialview01'>1kh6</scene>, resolution 2.9&Aring;
|SITE=
|SITE=
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|LIGAND=
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|LIGAND= <scene name='pdbligand=5BU:5-BROMO-URIDINE-5&#39;-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kh6 OCA], [http://www.ebi.ac.uk/pdbsum/1kh6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kh6 RCSB]</span>
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[[Category: translation]]
[[Category: translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:17:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:34 2008''

Revision as of 18:48, 30 March 2008

Image:1kh6.gif


PDB ID 1kh6

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands: , , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of an RNA Tertiary Domain Essential to HCV IRES-mediated Translation Initiation.


Overview

The hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA drives internal initiation of viral protein synthesis during host cell infection. In the tertiary structure of the IRES RNA, two helical junctions create recognition sites for direct binding of the 40S ribosomal subunit and eukaryotic initiation factor 3 (eIF3). The 2.8 A resolution structure of the IIIabc four-way junction, which is critical for binding eIF3, reveals how junction nucleotides interact with an adjacent helix to position regions directly involved in eIF3 recognition. Two of the emergent helices stack to form a nearly continuous A-form duplex, while stacking of the other two helices is interrupted by the insertion of junction residues into the helix minor groove. This distorted stack probably serves as an important recognition surface for the translational machinery.

About this Structure

1KH6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation., Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA, Nat Struct Biol. 2002 May;9(5):370-4. PMID:11927953

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