3sfh

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==Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor==
==Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor==
<StructureSection load='3sfh' size='340' side='right' caption='[[3sfh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3sfh' size='340' side='right' caption='[[3sfh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SFH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SFH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DI:(2R)-2-AMINO-3-(2,4-DICHLOROPHENYL)-1-(1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPAN-1-ONE'>1DI</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DI:(2R)-2-AMINO-3-(2,4-DICHLOROPHENYL)-1-(1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPAN-1-ONE'>1DI</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sff|3sff]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sff|3sff]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HDAC8, HDACL1, CDA07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HDAC8, HDACL1, CDA07 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_deacetylase Histone deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.98 3.5.1.98] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_deacetylase Histone deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.98 3.5.1.98] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sfh RCSB], [http://www.ebi.ac.uk/pdbsum/3sfh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfh OCA], [http://pdbe.org/3sfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sfh RCSB], [http://www.ebi.ac.uk/pdbsum/3sfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3sfh" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Histone deacetylase]]
[[Category: Histone deacetylase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Stams, T]]
[[Category: Stams, T]]
[[Category: Vash, B]]
[[Category: Vash, B]]
[[Category: Deacetylase]]
[[Category: Deacetylase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 07:18, 4 August 2016

Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor

3sfh, resolution 2.70Å

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