4k6l

From Proteopedia

(Difference between revisions)

Revision as of 07:42, 4 August 2016

Structure of Typhoid Toxin

Structural highlights

4k6l is a 7 chain structure with sequence from "bacillus_typhi"_schroeter_1886 "bacillus typhi" schroeter 1886. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	STY1891, t1107 ("Bacillus typhi" Schroeter 1886), cdtB, STY1886, t1111 ("Bacillus typhi" Schroeter 1886), STY1890, t1108 ("Bacillus typhi" Schroeter 1886)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CDTB_SALTI] Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.

Publication Abstract from PubMed

Salmonella enterica serovar Typhi (S. Typhi) differs from most other salmonellae in that it causes a life-threatening systemic infection known as typhoid fever. The molecular bases for its unique clinical presentation are unknown. Here we find that the systemic administration of typhoid toxin, a unique virulence factor of S. Typhi, reproduces many of the acute symptoms of typhoid fever in an animal model. We identify specific carbohydrate moieties on specific surface glycoproteins that serve as receptors for typhoid toxin, which explains its broad cell target specificity. We present the atomic structure of typhoid toxin, which shows an unprecedented A2B5 organization with two covalently linked A subunits non-covalently associated to a pentameric B subunit. The structure provides insight into the toxin's receptor-binding specificity and delivery mechanisms and reveals how the activities of two powerful toxins have been co-opted into a single, unique toxin that can induce many of the symptoms characteristic of typhoid fever. These findings may lead to the development of potentially life-saving therapeutics against typhoid fever.

Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin.,Song J, Gao X, Galan JE Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Song J, Gao X, Galan JE. Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500 doi:10.1038/nature12377

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4k6l"

@@ Line 1: / Line 1: @@
 ==Structure of Typhoid Toxin==
 <StructureSection load='4k6l' size='340' side='right' caption='[[4k6l]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STY1891, t1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886]), cdtB, STY1886, t1111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886]), STY1890, t1108 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90370 "Bacillus typhi" Schroeter 1886])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k6l RCSB], [http://www.ebi.ac.uk/pdbsum/4k6l PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6l OCA], [http://pdbe.org/4k6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k6l RCSB], [http://www.ebi.ac.uk/pdbsum/4k6l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k6l ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4k6l" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>

4k6l

From Proteopedia

Revision as of 07:42, 4 August 2016

Structure of Typhoid Toxin

Structural highlights

Function

Publication Abstract from PubMed

References

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