3saj

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Revision as of 08:00, 4 August 2016

Crystal Structure of glutamate receptor GluA1 Amino Terminal Domain

Structural highlights

3saj is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GRIA1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.^[1] ^[2]

Publication Abstract from PubMed

The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subfamily of ionotropic glutamate receptors (iGluRs) is essential for fast excitatory neurotransmission in the central nervous system. The malfunction of AMPARs has been implicated in many neurological diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The active channels of AMPARs and other iGluR subfamilies are tetramers formed exclusively by assembly of subunits within the same subfamily. It has been proposed that the assembly process is controlled mainly by the extracellular amino-terminal domain (ATD) of iGluR. In addition, ATD has also been implicated in synaptogenesis, iGluR trafficking, and trans-synaptic signaling, through unknown mechanisms. We report here a 2.5 A resolution crystal structure of the ATD of GluA1. Comparative analyses of the structure of GluA1-ATD and other subunits sheds light on our understanding of how ATD drives subfamily-specific assembly of AMPARs. In addition, analysis of the crystal lattice of GluA1-ATD suggests a novel mechanism by which the ATD might participate in inter-tetramer AMPAR clustering, as well as in trans-synaptic protein-protein interactions.

Crystal structure of the glutamate receptor GluA1 amino-terminal domain.,Yao G, Zong Y, Gu S, Zhou J, Xu H, Mathews II, Jin R Biochem J. 2011 Jun 6. PMID:21639859^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Bedoukian MA, Weeks AM, Partin KM. Different domains of the AMPA receptor direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics. J Biol Chem. 2006 Aug 18;281(33):23908-21. Epub 2006 Jun 22. PMID:16793768 doi:http://dx.doi.org/M600679200
↑ Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klocker N. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852. PMID:19265014 doi:10.1126/science.1167852
↑ Yao G, Zong Y, Gu S, Zhou J, Xu H, Mathews II, Jin R. Crystal structure of the glutamate receptor GluA1 amino-terminal domain. Biochem J. 2011 Jun 6. PMID:21639859 doi:10.1042/BJ20110801

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3saj"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of glutamate receptor GluA1 Amino Terminal Domain==
 <StructureSection load='3saj' size='340' side='right' caption='[[3saj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[3saj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SAJ FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3saj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3saj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3saj RCSB], [http://www.ebi.ac.uk/pdbsum/3saj PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3saj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3saj OCA], [http://pdbe.org/3saj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3saj RCSB], [http://www.ebi.ac.uk/pdbsum/3saj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3saj ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 16: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3saj" style="background-color:#fffaf0;"></div>
 ==See Also==

3saj

From Proteopedia

Revision as of 08:00, 4 August 2016

Crystal Structure of glutamate receptor GluA1 Amino Terminal Domain

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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