3prx
From Proteopedia
(Difference between revisions)
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| + | {{Large structure}} | ||
==Structure of Complement C5 in Complex with CVF and SSL7== | ==Structure of Complement C5 in Complex with CVF and SSL7== | ||
<StructureSection load='3prx' size='340' side='right' caption='[[3prx]], [[Resolution|resolution]] 4.30Å' scene=''> | <StructureSection load='3prx' size='340' side='right' caption='[[3prx]], [[Resolution|resolution]] 4.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3prx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3prx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885], [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PRX FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pvm|3pvm]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pvm|3pvm]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3prx RCSB], [http://www.ebi.ac.uk/pdbsum/3prx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3prx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prx OCA], [http://pdbe.org/3prx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3prx RCSB], [http://www.ebi.ac.uk/pdbsum/3prx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3prx ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | {{Large structure}} | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). | [[http://www.uniprot.org/uniprot/CO5_HUMAN CO5_HUMAN]] Defects in C5 are the cause of complement component 5 deficiency (C5D) [MIM:[http://omim.org/entry/609536 609536]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705). | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3prx" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Cobra venom factor|Cobra venom factor]] | *[[Cobra venom factor|Cobra venom factor]] | ||
| + | *[[Complement C5|Complement C5]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Naja kaouthia]] | [[Category: Naja kaouthia]] | ||
| - | [[Category: Staphylococcus aureus]] | ||
[[Category: Andersen, G R]] | [[Category: Andersen, G R]] | ||
[[Category: Andersen, K R]] | [[Category: Andersen, K R]] | ||
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[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Immune system-toxin complex]] | [[Category: Immune system-toxin complex]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
Revision as of 08:30, 4 August 2016
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Structure of Complement C5 in Complex with CVF and SSL7
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