4bm8
From Proteopedia
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==Galectin-3c in complex with Bisamido-thiogalactoside derivate 3== | ==Galectin-3c in complex with Bisamido-thiogalactoside derivate 3== | ||
<StructureSection load='4bm8' size='340' side='right' caption='[[4bm8]], [[Resolution|resolution]] 0.96Å' scene=''> | <StructureSection load='4bm8' size='340' side='right' caption='[[4bm8]], [[Resolution|resolution]] 0.96Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6J:(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>A6J</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6J:(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>A6J</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bli|4bli]], [[4blj|4blj]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bli|4bli]], [[4blj|4blj]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bm8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bm8 OCA], [http://pdbe.org/4bm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bm8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bm8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | [[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
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| + | ==See Also== | ||
| + | *[[Galectin|Galectin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 09:27, 4 August 2016
Galectin-3c in complex with Bisamido-thiogalactoside derivate 3
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