3n7o

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==X-ray structure of human chymase in complex with small molecule inhibitor.==
==X-ray structure of human chymase in complex with small molecule inhibitor.==
<StructureSection load='3n7o' size='340' side='right' caption='[[3n7o]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3n7o' size='340' side='right' caption='[[3n7o]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n7o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N7O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N7O:(S)-[(1S)-1-(5-CHLORO-1-BENZOTHIOPHEN-3-YL)-2-{[(E)-2-(3,4-DIFLUOROPHENYL)ETHENYL]AMINO}-2-OXOETHYL]METHYLPHOSPHINIC+ACID'>N7O</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N7O:(S)-[(1S)-1-(5-CHLORO-1-BENZOTHIOPHEN-3-YL)-2-{[(E)-2-(3,4-DIFLUOROPHENYL)ETHENYL]AMINO}-2-OXOETHYL]METHYLPHOSPHINIC+ACID'>N7O</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chymase (16-245), CMA1, CYH, CYM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chymase (16-245), CMA1, CYH, CYM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymase Chymase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.39 3.4.21.39] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymase Chymase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.39 3.4.21.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n7o RCSB], [http://www.ebi.ac.uk/pdbsum/3n7o PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n7o OCA], [http://pdbe.org/3n7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n7o RCSB], [http://www.ebi.ac.uk/pdbsum/3n7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n7o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n7o ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3n7o" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Chymase]]
[[Category: Chymase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Abad, M C]]
[[Category: Abad, M C]]
[[Category: Bayoumy, S]]
[[Category: Bayoumy, S]]

Revision as of 09:39, 4 August 2016

X-ray structure of human chymase in complex with small molecule inhibitor.

3n7o, resolution 1.80Å

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