4ezs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)== | ==Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)== | ||
<StructureSection load='4ezs' size='340' side='right' caption='[[4ezs]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4ezs' size='340' side='right' caption='[[4ezs]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ezs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4ezs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EZS FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dkx|1dkx]], [[1dky|1dky]], [[1dkz|1dkz]], [[3dpo|3dpo]], [[3dpp|3dpp]], [[3dpq|3dpq]], [[3qnj|3qnj]], [[4e81|4e81]], [[4ezn|4ezn]], [[4ezo|4ezo]], [[4ezp|4ezp]], [[4ezq|4ezq]], [[4ezr|4ezr]], [[4ezt|4ezt]], [[4ezu|4ezu]], [[4ezv|4ezv]], [[4ezw|4ezw]], [[4ezx|4ezx]], [[4ezy|4ezy]], [[4ezz|4ezz]], [[4f00|4f00]], [[4f01|4f01]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dkx|1dkx]], [[1dky|1dky]], [[1dkz|1dkz]], [[3dpo|3dpo]], [[3dpp|3dpp]], [[3dpq|3dpq]], [[3qnj|3qnj]], [[4e81|4e81]], [[4ezn|4ezn]], [[4ezo|4ezo]], [[4ezp|4ezp]], [[4ezq|4ezq]], [[4ezr|4ezr]], [[4ezt|4ezt]], [[4ezu|4ezu]], [[4ezv|4ezv]], [[4ezw|4ezw]], [[4ezx|4ezx]], [[4ezy|4ezy]], [[4ezz|4ezz]], [[4f00|4f00]], [[4f01|4f01]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0014, dnaK, groP, grpF, JW0013, seg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0014, dnaK, groP, grpF, JW0013, seg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ezs RCSB], [http://www.ebi.ac.uk/pdbsum/4ezs PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ezs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ezs OCA], [http://pdbe.org/4ezs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ezs RCSB], [http://www.ebi.ac.uk/pdbsum/4ezs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ezs ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/MTK_DROME MTK_DROME]] Potent antifungal and antibacterial activity against Gram-positive bacteria. | [[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/MTK_DROME MTK_DROME]] Potent antifungal and antibacterial activity against Gram-positive bacteria. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Proteins|Heat Shock Proteins]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Ecoli]] |
[[Category: Straeter, N]] | [[Category: Straeter, N]] | ||
[[Category: Zahn, M]] | [[Category: Zahn, M]] | ||
Revision as of 09:42, 4 August 2016
Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26)
| |||||||||||
