1kod

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 1kod |SIZE=350|CAPTION= <scene name='initialview01'>1kod</scene>
|PDB= 1kod |SIZE=350|CAPTION= <scene name='initialview01'>1kod</scene>
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>
+
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=[[1koc|1KOC]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kod OCA], [http://www.ebi.ac.uk/pdbsum/1kod PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kod RCSB]</span>
}}
}}
Line 26: Line 29:
[[Category: Westhof, E.]]
[[Category: Westhof, E.]]
[[Category: Yang, Y S.]]
[[Category: Yang, Y S.]]
-
[[Category: CIR]]
 
[[Category: in vitro selected rna]]
[[Category: in vitro selected rna]]
[[Category: rna aptamer]]
[[Category: rna aptamer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:20:06 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:51:20 2008''

Revision as of 18:51, 30 March 2008


PDB ID 1kod

Drag the structure with the mouse to rotate
Ligands: , , , ,
Related: 1KOC


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



RNA APTAMER COMPLEXED WITH CITRULLINE, NMR


Overview

In a previous study, an RNA aptamer for the specific recognition of arginine was evolved from a parent sequence that bound citrulline specifically. The two RNAs differ at only 3 positions out of 44. The solution structures of the two aptamers complexed to their cognate amino acids have now been determined by two-dimensional nuclear magnetic resonance spectroscopy. Both aptamers contain two asymmetrical internal loops that are not well ordered in the free RNA but that fold into a compact structure upon ligand binding. Those nucleotides common to both RNAs include a conserved cluster of purine residues, three of which form an uneven plane containing a G:G pair, and two other residues nearly perpendicular to that surface. Two of the three variant nucleotides are stacked on the cluster of purines and form a triple contact to the amino acid side chain, whereas the edge of the third variant nucleotide is capping the binding pocket.

About this Structure

1KOD is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy., Yang Y, Kochoyan M, Burgstaller P, Westhof E, Famulok M, Science. 1996 May 31;272(5266):1343-7. PMID:8650546

Page seeded by OCA on Sun Mar 30 21:51:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools