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3tj2
From Proteopedia
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==Structure of a novel submicromolar MDM2 inhibitor== | ==Structure of a novel submicromolar MDM2 inhibitor== | ||
<StructureSection load='3tj2' size='340' side='right' caption='[[3tj2]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3tj2' size='340' side='right' caption='[[3tj2]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3tj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3tj2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TJ2 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TJ2:3-{(1S)-2-(TERT-BUTYLAMINO)-1-[(4-CHLOROBENZYL)(FORMYL)AMINO]-2-OXOETHYL}-6-CHLORO-1H-INDOLE-2-CARBOXYLIC+ACID'>TJ2</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TJ2:3-{(1S)-2-(TERT-BUTYLAMINO)-1-[(4-CHLOROBENZYL)(FORMYL)AMINO]-2-OXOETHYL}-6-CHLORO-1H-INDOLE-2-CARBOXYLIC+ACID'>TJ2</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ycr|1ycr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ycr|1ycr]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tj2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tj2 RCSB], [http://www.ebi.ac.uk/pdbsum/3tj2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tj2 OCA], [http://pdbe.org/3tj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tj2 RCSB], [http://www.ebi.ac.uk/pdbsum/3tj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tj2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Doemling, A]] | [[Category: Doemling, A]] | ||
[[Category: Goda, S]] | [[Category: Goda, S]] | ||
Revision as of 10:24, 4 August 2016
Structure of a novel submicromolar MDM2 inhibitor
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