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4n78

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Revision as of 10:45, 4 August 2016

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

Structural highlights

4n78 is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	3p8c
Gene:	CYFIP1, KIAA0068 (HUMAN), NCKAP1, HEM2, KIAA0587, NAP1 (HUMAN), WASF1, KIAA0269, SCAR1, WAVE1 (HUMAN), BRK1, C3orf10, HSPC300, MDS027 (HUMAN), ABI2 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[CYFP1_HUMAN] Angelman syndrome.

Function

[BRK1_HUMAN] Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.^[1] [CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.^[2] ^[3] ^[4] ^[5] [WASF1_HUMAN] Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. [NCKP1_HUMAN] Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

Publication Abstract from PubMed

The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane sites. However, the factors that recruit the WRC to specific locations remain poorly understood. Here, we have identified a large family of potential WRC ligands, consisting of approximately 120 diverse membrane proteins, including protocadherins, ROBOs, netrin receptors, neuroligins, GPCRs, and channels. Structural, biochemical, and cellular studies reveal that a sequence motif that defines these ligands binds to a highly conserved interaction surface of the WRC formed by the Sra and Abi subunits. Mutating this binding surface in flies resulted in defects in actin cytoskeletal organization and egg morphology during oogenesis, leading to female sterility. Our findings directly link diverse membrane proteins to the WRC and actin cytoskeleton and have broad physiological and pathological ramifications in metazoans.

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.,Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK Cell. 2014 Jan 16;156(1-2):195-207. doi: 10.1016/j.cell.2013.11.048. PMID:24439376^[6]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Derivery E, Fink J, Martin D, Houdusse A, Piel M, Stradal TE, Louvard D, Gautreau A. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PLoS One. 2008 Jun 18;3(6):e2462. doi: 10.1371/journal.pone.0002462. PMID:18560548 doi:http://dx.doi.org/10.1371/journal.pone.0002462
↑ Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem. 1998 Jan 2;273(1):291-5. PMID:9417078
↑ Kawano Y, Yoshimura T, Tsuboi D, Kawabata S, Kaneko-Kawano T, Shirataki H, Takenawa T, Kaibuchi K. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol. 2005 Nov;25(22):9920-35. PMID:16260607 doi:http://dx.doi.org/25/22/9920
↑ Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell. 2009 Jun 12;137(6):1047-61. doi: 10.1016/j.cell.2009.04.013. PMID:19524508 doi:http://dx.doi.org/10.1016/j.cell.2009.04.013
↑ Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK. Structure and control of the actin regulatory WAVE complex. Nature. 2010 Nov 25;468(7323):533-8. PMID:21107423 doi:10.1038/nature09623
↑ Chen B, Brinkmann K, Chen Z, Pak CW, Liao Y, Shi S, Henry L, Grishin NV, Bogdan S, Rosen MK. The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton. Cell. 2014 Jan 16;156(1-2):195-207. doi: 10.1016/j.cell.2013.11.048. PMID:24439376 doi:http://dx.doi.org/10.1016/j.cell.2013.11.048

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4n78"

Categories: Human | Chen, Z C | Actin dynamic | Protein binding

@@ Line 1: / Line 1: @@
 ==The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton==
 <StructureSection load='4n78' size='340' side='right' caption='[[4n78]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p8c|3p8c]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYFIP1, KIAA0068 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NCKAP1, HEM2, KIAA0587, NAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), WASF1, KIAA0269, SCAR1, WAVE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), BRK1, C3orf10, HSPC300, MDS027 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ABI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n78 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n78 RCSB], [http://www.ebi.ac.uk/pdbsum/4n78 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n78 OCA], [http://pdbe.org/4n78 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n78 RCSB], [http://www.ebi.ac.uk/pdbsum/4n78 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n78 ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 20: / Line 21: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4n78" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>

4n78

From Proteopedia

Revision as of 10:45, 4 August 2016

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

Structural highlights

Disease

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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