1kq0
From Proteopedia
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|PDB= 1kq0 |SIZE=350|CAPTION= <scene name='initialview01'>1kq0</scene>, resolution 2.00Å | |PDB= 1kq0 |SIZE=350|CAPTION= <scene name='initialview01'>1kq0</scene>, resolution 2.00Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=MED:D-METHIONINE'>MED</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1kq9|1KQ9]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kq0 OCA], [http://www.ebi.ac.uk/pdbsum/1kq0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kq0 RCSB]</span> | ||
}} | }} | ||
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[[Category: Nonato, M C.]] | [[Category: Nonato, M C.]] | ||
[[Category: Widom, J.]] | [[Category: Widom, J.]] | ||
| - | [[Category: MED]] | ||
| - | [[Category: TBU]] | ||
| - | [[Category: ZN]] | ||
[[Category: central b-sheet and two pairs of a-helice]] | [[Category: central b-sheet and two pairs of a-helice]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:51:57 2008'' |
Revision as of 18:51, 30 March 2008
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Activity: | Methionyl aminopeptidase, with EC number 3.4.11.18 | ||||||
| Related: | 1KQ9
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human methionine aminopeptidase type II in complex with D-methionine
Overview
Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors.
About this Structure
1KQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:16540317
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