1kq8

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kq8 OCA], [http://www.ebi.ac.uk/pdbsum/1kq8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kq8 RCSB]</span>
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[[Category: winged helix protein]]
[[Category: winged helix protein]]
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Revision as of 18:52, 30 March 2008

Image:1kq8.jpg


PDB ID 1kq8

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Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Solution Structure of Winged Helix Protein HFH-1


Overview

The hepatocyte nuclear factor 3 (HNF-3)/fork head (fkh) family contains a large number of transcription factors that recognize divergent DNA sequences via a winged helix binding motif. HNF-3/fkh proteins show a broad profile of DNA sequence-specificity in which one DNA sequence can be recognized by more than one HNF-3/fkh protein and each individual HNF-3/fkh protein has several DNA binding sequences. In this study, heteronuclear NMR methods were used to study the structures of the DNA binding domain of a conserved winged helix protein HFH-1 and its DNA complexes. The structural comparison of winged helix proteins HFH-1 and Genesis and their DNA complexes indicates that even two highly conserved HNF-3 family members can adopt different local structures when they contact an identical DNA binding sequence, while one of these two HNF-3 proteins seems to adopt only slightly different structures on different DNA binding sites.

About this Structure

1KQ8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence., Sheng W, Rance M, Liao X, Biochemistry. 2002 Mar 12;41(10):3286-93. PMID:11876636

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