1kxk
From Proteopedia
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|PDB= 1kxk |SIZE=350|CAPTION= <scene name='initialview01'>1kxk</scene>, resolution 3.0Å | |PDB= 1kxk |SIZE=350|CAPTION= <scene name='initialview01'>1kxk</scene>, resolution 3.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxk OCA], [http://www.ebi.ac.uk/pdbsum/1kxk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kxk RCSB]</span> | ||
}} | }} | ||
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[[Category: Doudna, J A.]] | [[Category: Doudna, J A.]] | ||
[[Category: Zhang, L.]] | [[Category: Zhang, L.]] | ||
| - | [[Category: MG]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
[[Category: tetraloop]] | [[Category: tetraloop]] | ||
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[[Category: two-nucleotide bulge]] | [[Category: two-nucleotide bulge]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:55:04 2008'' |
Revision as of 18:55, 30 March 2008
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| , resolution 3.0Å | |||||||
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| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron
Overview
Group II self-splicing introns catalyze autoexcision from precursor RNA transcripts by a mechanism strikingly similar to that of the spliceosome, an RNA-protein assembly responsible for splicing together the protein-coding parts of most eukaryotic pre-mRNAs. Splicing in both cases initiates via nucleophilic attack at the 5' splice site by the 2' OH of a conserved intron adenosine residue, creating a branched (lariat) intermediate. Here, we describe the crystal structure at 3.0 A resolution of a 70-nucleotide RNA containing the catalytically essential domains 5 and 6 of the yeast ai5gamma group II self-splicing intron, revealing an unexpected two-nucleotide bulged structure around the branch-point adenosine in domain 6.
About this Structure
1KXK is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structural insights into group II intron catalysis and branch-site selection., Zhang L, Doudna JA, Science. 2002 Mar 15;295(5562):2084-8. Epub 2002 Feb 21. PMID:11859154
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