4k65
From Proteopedia
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==Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005== | ==Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005== | ||
<StructureSection load='4k65' size='340' side='right' caption='[[4k65]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4k65' size='340' side='right' caption='[[4k65]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4k65]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/indonesia/5/ | + | <table><tr><td colspan='2'>[[4k65]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/indonesia/5/05(h5n1)) Influenza a virus (a/indonesia/5/05(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K65 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k62|4k62]], [[4k63|4k63]], [[4k64|4k64]], [[4k66|4k66]], [[4k67|4k67]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k62|4k62]], [[4k63|4k63]], [[4k64|4k64]], [[4k66|4k66]], [[4k67|4k67]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=400788 Influenza A virus (A/Indonesia/5/ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=400788 Influenza A virus (A/Indonesia/5/05(H5N1))])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k65 RCSB], [http://www.ebi.ac.uk/pdbsum/4k65 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k65 OCA], [http://pdbe.org/4k65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k65 RCSB], [http://www.ebi.ac.uk/pdbsum/4k65 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k65 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A8HWY8_9INFA A8HWY8_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS00204388] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4k65" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
Revision as of 14:42, 4 August 2016
Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005
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Categories: Gao, G F | Lu, X | Qi, J | Shi, Y | Shu, Y | Zhang, W | Membrane fusion | Viral protein | Virus attachment
