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4jk3

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{{STRUCTURE_4jk3| PDB=4jk3 | SCENE= }}
 
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===PylD holoenzyme (SeMet)===
 
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{{ABSTRACT_PUBMED_23720358}}
 
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==About this Structure==
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==PylD holoenzyme (SeMet)==
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[[4jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_barkeri_str._fusaro Methanosarcina barkeri str. fusaro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK3 OCA].
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<StructureSection load='4jk3' size='340' side='right' caption='[[4jk3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metbf Metbf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JK3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j43|4j43]], [[4j49|4j49]], [[4j4b|4j4b]], [[4j4h|4j4h]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mbar_A0835 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269797 METBF])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jk3 OCA], [http://pdbe.org/4jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/4jk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jk3 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced-fit mechanism achieved by major structural rearrangements of the N-terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product.
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==Reference==
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Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).,Quitterer F, Beck P, Bacher A, Groll M Angew Chem Int Ed Engl. 2013 May 29. doi: 10.1002/anie.201301164. PMID:23720358<ref>PMID:23720358</ref>
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<ref group="xtra">PMID:023720358</ref><references group="xtra"/><references/>
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[[Category: Methanosarcina barkeri str. fusaro]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Bacher, A.]]
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</div>
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[[Category: Beck, P.]]
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<div class="pdbe-citations 4jk3" style="background-color:#fffaf0;"></div>
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[[Category: Groll, M.]]
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== References ==
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[[Category: Quitterer, F.]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Metbf]]
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[[Category: Bacher, A]]
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[[Category: Beck, P]]
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[[Category: Groll, M]]
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[[Category: Quitterer, F]]
[[Category: 22nd amino acid]]
[[Category: 22nd amino acid]]
[[Category: Biosynthesis]]
[[Category: Biosynthesis]]

Revision as of 14:52, 4 August 2016

PylD holoenzyme (SeMet)

4jk3, resolution 2.50Å

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