4jk3
From Proteopedia
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| - | {{STRUCTURE_4jk3| PDB=4jk3 | SCENE= }} | ||
| - | ===PylD holoenzyme (SeMet)=== | ||
| - | {{ABSTRACT_PUBMED_23720358}} | ||
| - | == | + | ==PylD holoenzyme (SeMet)== |
| - | [[4jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <StructureSection load='4jk3' size='340' side='right' caption='[[4jk3]], [[Resolution|resolution]] 2.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jk3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metbf Metbf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JK3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j43|4j43]], [[4j49|4j49]], [[4j4b|4j4b]], [[4j4h|4j4h]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mbar_A0835 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269797 METBF])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jk3 OCA], [http://pdbe.org/4jk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jk3 RCSB], [http://www.ebi.ac.uk/pdbsum/4jk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jk3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced-fit mechanism achieved by major structural rearrangements of the N-terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product. | ||
| - | + | Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD).,Quitterer F, Beck P, Bacher A, Groll M Angew Chem Int Ed Engl. 2013 May 29. doi: 10.1002/anie.201301164. PMID:23720358<ref>PMID:23720358</ref> | |
| - | <ref | + | |
| - | [[Category: | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | [[Category: Bacher, A | + | </div> |
| - | [[Category: Beck, P | + | <div class="pdbe-citations 4jk3" style="background-color:#fffaf0;"></div> |
| - | [[Category: Groll, M | + | == References == |
| - | [[Category: Quitterer, F | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Metbf]] | ||
| + | [[Category: Bacher, A]] | ||
| + | [[Category: Beck, P]] | ||
| + | [[Category: Groll, M]] | ||
| + | [[Category: Quitterer, F]] | ||
[[Category: 22nd amino acid]] | [[Category: 22nd amino acid]] | ||
[[Category: Biosynthesis]] | [[Category: Biosynthesis]] | ||
Revision as of 14:52, 4 August 2016
PylD holoenzyme (SeMet)
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Categories: Metbf | Bacher, A | Beck, P | Groll, M | Quitterer, F | 22nd amino acid | Biosynthesis | Dehydrogenase | Nad | Oxidoreductase | Pyrrolysine | Rossmann fold
