4bky
From Proteopedia
(Difference between revisions)
Line 1: | Line 1: | ||
+ | |||
==Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor== | ==Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor== | ||
<StructureSection load='4bky' size='340' side='right' caption='[[4bky]], [[Resolution|resolution]] 1.83Å' scene=''> | <StructureSection load='4bky' size='340' side='right' caption='[[4bky]], [[Resolution|resolution]] 1.83Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4bky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4bky]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKY FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82B:3-{[(4-BROMO-1-METHYL-1H-PYRROL-2-YL)CARBONYL]AMINO}-N-[(1S)-1-PHENYL-2-(PYRROLIDIN-1-YL)ETHYL]-1,4-DIHYDRO-5H-SPIRO[CYCLOPROPANE-1,6-PYRROLO[3,4-C]PYRAZOLE]-5-CARBOXAMIDE'>82B</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82B:3-{[(4-BROMO-1-METHYL-1H-PYRROL-2-YL)CARBONYL]AMINO}-N-[(1S)-1-PHENYL-2-(PYRROLIDIN-1-YL)ETHYL]-1,4-DIHYDRO-5H-SPIRO[CYCLOPROPANE-1,6-PYRROLO[3,4-C]PYRAZOLE]-5-CARBOXAMIDE'>82B</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bkz|4bkz]], [[4bl1|4bl1]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bkz|4bkz]], [[4bl1|4bl1]]</td></tr> | ||
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bky RCSB], [http://www.ebi.ac.uk/pdbsum/4bky PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bky OCA], [http://pdbe.org/4bky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bky RCSB], [http://www.ebi.ac.uk/pdbsum/4bky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bky ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
Line 19: | Line 20: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
+ | <div class="pdbe-citations 4bky" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Human]] |
[[Category: Bertrand, J A]] | [[Category: Bertrand, J A]] | ||
[[Category: Canevari, G]] | [[Category: Canevari, G]] |
Revision as of 14:53, 4 August 2016
Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor
|