3wym
From Proteopedia
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==Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one== | ==Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one== | ||
<StructureSection load='3wym' size='340' side='right' caption='[[3wym]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3wym' size='340' side='right' caption='[[3wym]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3K9:1-[2-FLUORO-4-(1H-PYRAZOL-1-YL)PHENYL]-5-METHOXY-3-(1-PHENYL-1H-PYRAZOL-5-YL)PYRIDAZIN-4(1H)-ONE'>3K9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3K9:1-[2-FLUORO-4-(1H-PYRAZOL-1-YL)PHENYL]-5-METHOXY-3-(1-PHENYL-1H-PYRAZOL-5-YL)PYRIDAZIN-4(1H)-ONE'>3K9</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wyk|3wyk]], [[3wyl|3wyl]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wyk|3wyk]], [[3wyl|3wyl]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wym OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wym RCSB], [http://www.ebi.ac.uk/pdbsum/3wym PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wym OCA], [http://pdbe.org/3wym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wym RCSB], [http://www.ebi.ac.uk/pdbsum/3wym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wym ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | [[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
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| + | ==See Also== | ||
| + | *[[Phosphodiesterase|Phosphodiesterase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 15:43, 4 August 2016
Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
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