3rx4
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide== | ==Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide== | ||
<StructureSection load='3rx4' size='340' side='right' caption='[[3rx4]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3rx4' size='340' side='right' caption='[[3rx4]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3rx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3rx4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SFI:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFANYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SFI</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SFI:2-[(3Z)-6-FLUORANYL-2-METHYL-3-[(4-METHYLSULFANYLPHENYL)METHYLIDENE]INDEN-1-YL]ETHANOIC+ACID'>SFI</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rx2|3rx2]], [[3rx3|3rx3]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rx2|3rx2]], [[3rx3|3rx3]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rx4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx4 OCA], [http://pdbe.org/3rx4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rx4 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rx4 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 19: | Line 20: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3rx4" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 27: | Line 29: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Aldehyde reductase]] | [[Category: Aldehyde reductase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Chen, J]] | [[Category: Chen, J]] | ||
[[Category: Hu, X]] | [[Category: Hu, X]] | ||
Revision as of 17:05, 4 August 2016
Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide
| |||||||||||
Categories: Aldehyde reductase | Human | Chen, J | Hu, X | Luo, H | Zheng, X | Aldose reductase | Oxidoreductase
