1l3w
From Proteopedia
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|PDB= 1l3w |SIZE=350|CAPTION= <scene name='initialview01'>1l3w</scene>, resolution 3.08Å | |PDB= 1l3w |SIZE=350|CAPTION= <scene name='initialview01'>1l3w</scene>, resolution 3.08Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ncg|1NCG]], [[1nch|1NCH]], [[1nci|1NCI]], [[1edh|1EDH]], [[1ff5|1FF5]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l3w OCA], [http://www.ebi.ac.uk/pdbsum/1l3w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l3w RCSB]</span> | ||
}} | }} | ||
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[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
[[Category: Wong, E.]] | [[Category: Wong, E.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: NAG]] | ||
| - | [[Category: NDG]] | ||
[[Category: cadherin]] | [[Category: cadherin]] | ||
[[Category: calcium binding]] | [[Category: calcium binding]] | ||
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[[Category: extracellular]] | [[Category: extracellular]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:57:39 2008'' |
Revision as of 18:57, 30 March 2008
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| , resolution 3.08Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1NCG, 1NCH, 1NCI, 1EDH, 1FF5
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
C-cadherin Ectodomain
Overview
Cadherins are transmembrane proteins that mediate adhesion between cells in the solid tissues of animals. Here we present the 3.1 angstrom resolution crystal structure of the whole, functional extracellular domain from C-cadherin, a representative "classical" cadherin. The structure suggests a molecular mechanism for adhesion between cells by classical cadherins, and it provides a new framework for understanding both cis (same cell) and trans (juxtaposed cell) cadherin interactions. The trans adhesive interface is a twofold symmetric interaction defined by a conserved tryptophan side chain at the membrane-distal end of a cadherin molecule from one cell, which inserts into a hydrophobic pocket at the membrane-distal end of a cadherin molecule from the opposing cell.
About this Structure
1L3W is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
C-cadherin ectodomain structure and implications for cell adhesion mechanisms., Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L, Science. 2002 May 17;296(5571):1308-13. Epub 2002 Apr 18. PMID:11964443
Page seeded by OCA on Sun Mar 30 21:57:39 2008
