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3i25
From Proteopedia
(Difference between revisions)
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==Potent Beta-Secretase 1 hydroxyethylene Inhibitor== | ==Potent Beta-Secretase 1 hydroxyethylene Inhibitor== | ||
<StructureSection load='3i25' size='340' side='right' caption='[[3i25]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3i25' size='340' side='right' caption='[[3i25]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3i25]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3i25]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I25 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MV7:N-[(2S,3S,5R)-1-(3,5-DIFLUOROPHENOXY)-3-HYDROXY-5-(2-METHOXYETHOXY)-6-[[(2S)-3-METHYL-1-OXO-1-(PHENYLMETHYLAMINO)BUTAN-2-YL]AMINO]-6-OXO-HEXAN-2-YL]-5-(METHYL-METHYLSULFONYL-AMINO)-N-[(1R)-1-PHENYLETHYL]BENZENE-1,3-DICARBOXAMIDE'>MV7</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MV7:N-[(2S,3S,5R)-1-(3,5-DIFLUOROPHENOXY)-3-HYDROXY-5-(2-METHOXYETHOXY)-6-[[(2S)-3-METHYL-1-OXO-1-(PHENYLMETHYLAMINO)BUTAN-2-YL]AMINO]-6-OXO-HEXAN-2-YL]-5-(METHYL-METHYLSULFONYL-AMINO)-N-[(1R)-1-PHENYLETHYL]BENZENE-1,3-DICARBOXAMIDE'>MV7</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i25 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i25 RCSB], [http://www.ebi.ac.uk/pdbsum/3i25 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i25 OCA], [http://pdbe.org/3i25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i25 RCSB], [http://www.ebi.ac.uk/pdbsum/3i25 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i25 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i25 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3i25" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Borkakoti, N]] | [[Category: Borkakoti, N]] | ||
Revision as of 18:03, 4 August 2016
Potent Beta-Secretase 1 hydroxyethylene Inhibitor
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Categories: Human | Memapsin 2 | Borkakoti, N | Lindberg, J D | Nystrom, S | Aspartyl protease | Bace | Beta-secretase | Disulfide bond | Glycoprotein | Hydrolase | Inhibitor | Membrane | Protease | Transmembrane | Zymogen
