1l6o
From Proteopedia
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|PDB= 1l6o |SIZE=350|CAPTION= <scene name='initialview01'>1l6o</scene>, resolution 2.200Å | |PDB= 1l6o |SIZE=350|CAPTION= <scene name='initialview01'>1l6o</scene>, resolution 2.200Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l6o OCA], [http://www.ebi.ac.uk/pdbsum/1l6o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l6o RCSB]</span> | ||
}} | }} | ||
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[[Category: wnt pathway]] | [[Category: wnt pathway]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:58:49 2008'' |
Revision as of 18:58, 30 March 2008
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| , resolution 2.200Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
XENOPUS DISHEVELLED PDZ DOMAIN
Overview
Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development.
About this Structure
1L6O is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation., Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT, Dev Cell. 2002 Apr;2(4):449-61. PMID:11970895
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