4n9n

Structural highlights

Function

[UPC2_YEAST] Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation.^{[1] [2] [3] [4] [5]}

References

1. ↑ Abramova NE, Cohen BD, Sertil O, Kapoor R, Davies KJ, Lowry CV. Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae. Genetics. 2001 Mar;157(3):1169-77. PMID:11238402
2. ↑ Abramova N, Sertil O, Mehta S, Lowry CV. Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol. 2001 May;183(9):2881-7. PMID:11292809 doi:http://dx.doi.org/10.1128/JB.183.9.2881-2887.2001
3. ↑ Vik A, Rine J. Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol. 2001 Oct;21(19):6395-405. PMID:11533229
4. ↑ Wilcox LJ, Balderes DA, Wharton B, Tinkelenberg AH, Rao G, Sturley SL. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. J Biol Chem. 2002 Sep 6;277(36):32466-72. Epub 2002 Jun 20. PMID:12077145 doi:http://dx.doi.org/10.1074/jbc.M204707200
5. ↑ Ter Linde JJ, Regnacq M, Steensma HY. Transcriptional regulation of YML083c under aerobic and anaerobic conditions. Yeast. 2003 Apr 15;20(5):439-54. PMID:12673627 doi:http://dx.doi.org/10.1002/yea.975