3svf
From Proteopedia
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==Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand== | ==Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand== | ||
<StructureSection load='3svf' size='340' side='right' caption='[[3svf]], [[Resolution|resolution]] 1.98Å' scene=''> | <StructureSection load='3svf' size='340' side='right' caption='[[3svf]], [[Resolution|resolution]] 1.98Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3svf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3svf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SVF FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WDR:(4S)-6-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-4-(2-HYDROXYETHOXY)-3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>WDR</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WDR:(4S)-6-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-4-(2-HYDROXYETHOXY)-3-METHYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE'>WDR</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3svg|3svg]], [[3svh|3svh]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3svg|3svg]], [[3svh|3svh]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3svf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3svf RCSB], [http://www.ebi.ac.uk/pdbsum/3svf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3svf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svf OCA], [http://pdbe.org/3svf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3svf RCSB], [http://www.ebi.ac.uk/pdbsum/3svf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3svf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
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| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 20:18, 4 August 2016
Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand
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