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4a54
From Proteopedia
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==Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6== | ==Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6== | ||
<StructureSection load='4a54' size='340' side='right' caption='[[4a54]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''> | <StructureSection load='4a54' size='340' side='right' caption='[[4a54]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4a54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4a54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A54 FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a6t|2a6t]], [[4a53|4a53]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a6t|2a6t]], [[4a53|4a53]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a54 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a54 RCSB], [http://www.ebi.ac.uk/pdbsum/4a54 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a54 OCA], [http://pdbe.org/4a54 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a54 RCSB], [http://www.ebi.ac.uk/pdbsum/4a54 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a54 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/DCP2_SCHPO DCP2_SCHPO]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> | + | [[http://www.uniprot.org/uniprot/EDC3_SCHPO EDC3_SCHPO]] Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation.<ref>PMID:22085934</ref> [[http://www.uniprot.org/uniprot/DCP2_SCHPO DCP2_SCHPO]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4a54" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Cbs 356]] |
[[Category: Braun, J E]] | [[Category: Braun, J E]] | ||
[[Category: Fromm, S A]] | [[Category: Fromm, S A]] | ||
Revision as of 20:34, 4 August 2016
Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6
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