1lfa
From Proteopedia
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|PDB= 1lfa |SIZE=350|CAPTION= <scene name='initialview01'>1lfa</scene>, resolution 1.8Å | |PDB= 1lfa |SIZE=350|CAPTION= <scene name='initialview01'>1lfa</scene>, resolution 1.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lfa OCA], [http://www.ebi.ac.uk/pdbsum/1lfa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lfa RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Leahy, D J.]] | [[Category: Leahy, D J.]] | ||
[[Category: Qu, A.]] | [[Category: Qu, A.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: MN]] | ||
[[Category: cell adhesion]] | [[Category: cell adhesion]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:02:06 2008'' |
Revision as of 19:02, 30 March 2008
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| , resolution 1.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CD11A I-DOMAIN WITH BOUND MN++
Overview
We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease.
About this Structure
1LFA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin., Qu A, Leahy DJ, Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10277-81. PMID:7479767
Page seeded by OCA on Sun Mar 30 22:02:06 2008
